Ethanecarboxylic acid, 617

N,N'-1,2-Ethanediylbis[N- (carboxymethyl)glycine, dipotassium salt, 261

N,N-1,2-Ethanediylbis[N- (carboxymethyl)glycine], 260

tetrasodium salt, 262

trisodium salt, 262

Ethanoic acid, 6

Ethanol, 18–20

anhydrous, 19

dilute, 20

Ethanol (96%), 18

Ethanolamine, 478

Ethanolic acid, 6

Ethanolum (96 per centum), 18

1,2-Ethenedicarboxylic acid, 293

Ethenol, homopolymer, 592

Ethenyl-2-pyrrolidinone homopolymer, 214, 611

Ethiops iron, 364

Ethispheres, 132

Ethocel, 278

Ethol, 155

3-Ethoxy-4-hydroxybenzaldehyde, 276 Ethoxylated fatty acid esters, 585 Ethyl acetate, 268

Ethyl alcohol, 18

Ethyl benzene-1,2-dicarboxylate, 240 Ethyl cellulose, with cellulose acetate

phthalate, 145

Ethyl ethanoate, 268

Ethyl gallate, 620

Ethyl hydroxide, 18

Ethyl hydroxybenzoate, 287

Ethyl 4-hydroxybenzoate potassium salt, 289 Ethyl 4-hydroxybenzoate sodium salt, 289 Ethyl a-hydroxypropionate, 270

Ethyl lactate, 270

Ethyl linoleate, 414

Ethyl maltol, 272, 446

Ethyl (2-mercaptobenzoato-S)-mercury, sodium salt, 777

Ethyl 9-octadecenoate, 274

Ethyl oleate, 274, 495

Ethyl parahydroxybenzoate, 287

Ethyl parasept, 287

Ethyl phthalate, 240

Ethyl pyromeconic acid, 272

Ethyl (sodium o-mercaptobenzoato)mercury, 777

Ethyl 3,4,5-trihydroxybenzoate, 620

Ethyl vanillin, 276, 799

Ethyl-3-hydroxy-4H-pyran-4-one, 272

Ethylan C, 564

Ethylcellulose, 278, 335, 352, 464 Ethylcellulose, compatible plasticizers, 281 Ethylcellulosum, 278

Ethylene fluoride, 242

Ethylene glycol monopalmitate, 283–284 Ethylene glycol monopalmitostearate, 283 Ethylene glycol monostearate, 283–284 Ethylene glycol palmitostearate, 283 Ethylene glycol stearate, 284

Ethylene glycoli monostearas, 284 Ethylene vinyl acetate, 285

Ethylene vinyl acetate copolymer, 285 Ethylenebis(iminodiacetic acid)

dipotassium salt, 261

tetrasodium salt, 262

Ethylenediaminetetraacetic acid, 260 calcium disodium chelate, 262 dipotassium salt, 261

900 Index

Ethylenediaminetetraacetic acid (cont.) disodium salt, 255

tetrasodium salt, 262

trisodium salt, 262

trans-1,2-Ethylenedicarboxylic acid, 293 [(Ethylenedinitrilo)tetraacetato]calciate(2-)

disodium, 262

(ethylenedinitrilo)Tetraacetic acid, 260

dipotassium salt, 261

tetrasodium salt, 262

trisodium salt, 262 Ethyleneglycol monophenyl ether, 517 Ethylene/vinyl acetate copolymer, 285

Ethylenglycoli monopalmitostearas, 283 Ethyleni glycoli stearas, 284 Ethylformic acid, 617

sodium salt, hydrate, 699

N-Ethylglucamine, 458

Ethylhydroxy cellulose, 330

Ethyl-2-hydroxypropanoate, 270

Ethyl-2-hydroxypropionate, 270

Ethyl-S-(–)-2-hydroxypropionate, 270

Ethylic acid, 6

Ethylis acetas, 268

Ethylis oleas, 274

Ethylis parahydroxybenzoas, 287 Ethyl[2-mercaptobenzoato(2-)-O,S]-

mercurate(1-) sodium, 777

Ethylolamine, 478

Ethylose, 330

Ethylparaben, 85, 287, 468, 631

see also Parabens Ethylparaben potassium, 289

Ethylparaben sodium, 289

Ethylprotal, 276

Ethylprotocatechuic aldehyde, 276

Etocas, 572

Eudragit, 553

Eudragit E, 554

Eudragit FS, 554

Eudragit L, 554

Eudragit L 30 D-55, 554 Eudragit L 30D, 589 Eudragit L 100-55, 554

Eudragit NE 30, 554 Eudragit NE 30D, 554 Eudragit NE 400, 554

Eudragit RD 100, 554

Eudragit RL, 554

Eudragit RS, 427, 554

Eudragit S, 554

Eumulgin, 572 Eutanol G PH, 492 EVA, 285

EVA copolymer, 285

EVM, 285

Explocel, 211

Explosol, 701

Explotab, 701

Expressed almond oil, 30 Exsiccated calcium sulfate, 106 Exsiccated sodium sulfite, 708

Extended-release agents see Sustained-release agents

Extra virgin olive oil, 499 Extract of carob, 149

Extractants, propylene glycol, 624

Famotidine, 783

Fancol, 130

Fatty acid esters, ethoxylated, 585 FD&C blue #2, 197

FD&C yellow #5, 198

FD&C yellow #6, 198

Fermine, 248

Ferric ferrous oxide, 364 Ferric hydrate, 364

Ferric hydroxide, 364 Ferric hydroxide oxide, 364 Ferric oxide hydrated, 364 Ferroan saponite, 644

Ferrosoferric oxide, 364

Fibrocel, 132

Fillers see Diluents (tablet/capsule)

Film-forming agents ammonium alginate, 46

chitosan, 159

chlorpheniramine maleate, 339

copovidone, 201

dibutyl phthalate, 234

dibutyl sebacate, 236

diethyl phthalate, 240

dimethyl phthalate, 248

ethyl lactate, 270

ethylcellulose, 278

gelatin, 295

hydroxyethyl cellulose, 330

hydroxypropyl cellulose, 336, 339

hypromellose, 346

hypromellose acetate succinate, 350 maltodextrin, 442

opacifiers, calcium carbonate, 89 polydextrose, 542

polyethylene glycol, 546–547

polyethylene oxide, 551

polymethacrylates, 554 poly(methylvinyl ether/maleic

anhydride), 561

polyvinyl acetate phthalate, 589 triethyl citrate, 796

vanillin, 798

see also Coating agents Fine virgin olive oil, 499 Finetose, 447

Finetose F, 447

Finlac DC, 383–384

Finmalt L, 440

Finnfix, 120

Fixatives, perfume, diethyl phthalate, 240

Flavinol, 780 Flavor enhancers

acesulfame potassium, 4

aspartame, 53

citric acid monohydrate, 185 dibutyl sebacate, 236

ethyl maltol, 272

ethylcellulose, 278

fructose, 290

maltol, 445

monosodium glutamate, 480

neohesperidin dihydrochalcone, 486

saccharin, 638

saccharin sodium, 641

sodium cyclamate, 678

tartaric acid, 770

thaumatin, 775

trehalose, 788

xylitol, 824 Flavoring agents

confectioner’s sugar, 750

denatonium benzoate, 224

dibutyl sebacate, 236

ethyl acetate, 268

ethyl lactate, 270

ethyl maltol, 272

ethyl vanillin, 276

fumaric acid, 293

leucine, 412

malic acid, 436

maltol, 445

menthol, 459

phosphoric acid, 530

propionic acid, 618

propylene glycol alginate, 627 sodium acetate, 654

sodium lactate, 685

sodium propionate, 699

thymol, 780

triethyl citrate, 796

vanillin, 798

Flavoring fixatives, ethylcellulose, 278

Flolys, 299

FlowLac 100, 396

Fluftex W, 725

Fluidamid R444P, 734

Fluorocarbon 134a, 772

Fluorocarbon emulsifying agents, poloxamer, 535

Foaming agents, polyethylene alkyl ethers, 565

Folic acid, 428

Forlan 500, 512

Formaldehyde, 423

Forsterite, 429

Freeze-drying stabilizers/carriers albumin, 16

lactose, anhydrous, 385

mannitol, 449

sodium bicarbonate, 665

trehalose, 788

see also Cryoprotectants French chalk, purified, 767 Freon, 176

Frigen, 176

Frigen 22, 175

Frigen 134a, 772

Fructamyl, 290

b-D-Fructofuranosyl-O-a-D-galactopyranosyl- (1→6)-a-D-glucopyranoside

anhydrous, 635

pentahydrate, 635

b-D-Fructofuranosyl-a-D-glucopyranoside, 744

D-(-)-Fructopyranose, 290

Fructose, 233, 290

furanose form, 292

high-fructose syrup, 292

invert sugar, 747

liquid, 292

with povidone, 290

powdered, 292

pyranose form, 292

with silicon dioxide, 292 sweetness vs.dextrose, 290

sweetness vs.sucrose, 290, 292

b-D-Fructose, 290

Fructosum, 290

Fruit sugar, 290

Frutafit, 362

Fujicalin, 93–94

Fumaric acid, 187, 293, 437, 705, 771

Fumed silica, 188 Fuming sulfuric acid, 759

Fungicides see Antifungal agents Fused borax, 670

Fused sodium borate, 670

Galactomannan, 148

Galactomannan polysaccharide, 315

Index 901

Galactomannans, guar gum, 315 Galactomannoglycone, ceratonia, 149 O-b-D-Galactopyranosyl-(1→4)-b-D-

glucopyranose, 385

O-b-D-Galactopyranosyl-(1→4)-a-D- glucopyranose monohydrate, 389, 396

4-O-(b-D-Galactopyranosyl)-D-glucitol, 383

dihydrate, 383

monohydrate, 383

b-Galactosido-sorbitol, 383

Galactosol, 315

Galen IQ, 366

Gallic acid propyl ester, 619

Gallotox, 521

Gamma cyclodextrin, 217

Gamma tocopherol, 33–34

Gantrez AN-119, 561

Gantrez AN-139, 561

Gantrez AN-149, 561

Gantrez AN-169, 561

Gantrez AN-179, 561

Gantrez AN-903, 561

Gantrez ES-225, 561

Gantrez ES-425, 561

Gantrez MS-955, 561

Gantrez S-95, 561

Gantrez S-96, 561

Gantrez S-97, 561

Garantose, 638 Gas-forming agents

potassium bicarbonate, 598

sodium bicarbonate, 665

Gelatin, 34, 295, 452

absorbable, 295

hard capsules, 295, 800 plasticizers

glycerin, 295, 301

mannitol, 449

sorbitol, 295, 718

soft capsules, 295

Gelatin sponge, 295

Gelatina, 295

Gelatine, 295

Gelcarin, 124 Gelling agents

aluminum stearate, 42

calcium silicate, 435

carbomers, 114

carboxymethylcellulose sodium, 120

carrageenan, 124

chitosan, 159

colloidal silicon dioxide, 188 gelatin, 295

glyceryl monooleate, 306

glyceryl palmitostearate, 311

guar gum, 316

hydroxyethyl cellulose, 333 microcrystalline cellulose and

carboxymethylcellulose sodium, 134

pectin, 507

polyethylene alkyl ethers, 565 polyethylene glycol, 546

polyethylene oxide, 551

polymethacrylates, 554

propylene carbonate, 622

sodium ascorbate, 659

sorbitol, 719

zinc acetate, 830

see also Hydrogels; Stiffening agents; Thickening agents; Viscosity-increasing agents

Gelosa, 14

Gelose, 14



Gelsorb, 418

Gelvatol, 592

Genetron, 176

Genetron 134a, 772

Genetron 142b, 174

Genetron 152a, 242

Genoplast B, 234

Genu, 124

Germall 115, 359

Germall II, 360

Ghassoulite, 318

Gingelly oil, 646

Gingili oil, 646

Ginseng, Korean red, 446 Glacial acetic acid, 6 Glaze, pharmaceutical, 650 Glidants

calcium phosphate, tribasic, 100 calcium silicate, 435

cellulose, powdered, 136 colloidal silicon dioxide, 188 magnesium silicate, 428

magnesium trisilicate, 434

silicon dioxide, 292

starch, 725

talc, 767

Glipizide, 458

Glucens, substituted, 161

Glucidex, 442

D-Glucitol, 718

Glucodry, 442

Glucomalt, 299

D-(+)-Glucopyranose, anhydrous, 233

D-(+)-Glucopyranose monohydrate, 231

a-D-glucopyranosyl-b-D-Fructofuranoside, 744

4-O-a-D-Glucopyranosyl-D-glucitol, 438

4-O-a-D-Glucopyranosyl-b-D-glucopyranose anhydrous, 447

4-O-a-D-Glucopyranosyl-b-D-glucopyranose monohydrate, 447

a-D-Glucopyranosyl-a-D-glucopyranoside anhydrous, 788

a-D-Glucopyranosyl-a-D-glucopyranoside dihydrate, 788

4-O-a-D-Glucopyranosyl-b-D-glucose, 447 1-O-a-D-glucopyranosyl-D-mannitol

dihydrate (1,1-GPM), 366

6-O-a-D-glucopyranosyl-D-sorbitol (1,6-GPS), 366

Glucosaccharonic acid, 264

Glucose, 231

anhydrous, 233

liquid, 229, 233, 299, 448

D-Glucose, and polydextrose, 543 Glucose monohydrate, 231

D-(+)-Glucose monohydrate, 231

Glucose syrup, 299

hydrogenated, 440

4-(a-D-Glucosido)-D-glucose, 447

(a-D-Glucosido)-a-D-glucoside, 788

Glucosum liquidum, 299

Glucosum monohydricum, 231

Glucosweet, 299

Gluside, 638

soluble, 641

Glutamic acid monosodium salt, 480 Glutamic acid monosodium salt

monohydrate, 480

Glutamic acid, sodium salt, 480 Glycerides

almond oil, 30

hydrogenated vegetable, 762



Glycerin, 301, 624, 765

concentrated, 301

Glycerin monostearate, 308

Glycerin palmitostearate, 311 Glycerin solutions, diluted, 303 Glycerine, 301

Glycerine monostearate, 308

Glycerol, 301

Glycerol (85 per cent), 303

Glycerol behenate, 304

Glycerol dibehenate, 304

Glycerol mono-oleates, 306

Glycerol monostearate, 308

Glycerol palmitostearate, 311

Glycerol stearate, 308

Glycerol triacetate, 790

Glyceroli dibehenas, 304

Glyceroli mono-oleates, 306

Glyceroli monostearas 40-55, 308

Glycerol-1-oleate, 306

Glycerolum, 301

Glycerolum tricacetas, 790

Glyceryl behenate, 304, 312

Glyceryl dibehenate, 304

Glyceryl monobehenate, 304

Glyceryl monooleate, 306, 310

Glyceryl monostearate, 283, 307–308, 312

self-emulsifying, 310

Glyceryl monostearate 40-55, 308

Glyceryl palmitostearate, 283, 305, 310–311

Glyceryl stearate, 308

Glyceryl triacetate, 790

Glyceryl tribehenate, 304

Glyceryl tricaprylate/caprate, 454

Glyceryl-tri-(12-hydroxystearate), 130

Glycofurol, 313

Glycofurol 75, 313–314

Glycolys, 701

Glycon, 494

Glycon G-100, 301

Glypesin, 323

GMS, 308

Goat’s thorn, 785

Gohsenol, 592

Gomenoleo oil, 498 Gomme de caroube, 148 Gossypol, 206

Gossypose, 635

Grain alcohol, 18 Granulating agents

copovidone, 201

glucose, liquid, 299

isomalt, 366

maltitol, 438

polydextrose, 542

sucrose, 744

Grape sugar, 231

Griffithite, 644

Groco, 494

Groundnut oil, 505

Guar acetate, 316

Guar acetate phthalate, 316 Guar flour, 315

Guar galactomannan, 315

Guar galactomannanum, 315

Guar gum, 2, 315–316, 822

and microcrystalline cellulose, 134 oxidized, 316

Guar phthalate, 316

oxo-L-Gulofuranolactone 6-palmitate, 51 3-oxo-L-Gulofuranolactone, enol form, 48 3-oxo-L-Gulofuranolactone sodium enolate,

659

902 Index

L-Gulo-D-mannoglycuronan, 21

Gum acacia, 1

Gum arabic, 1

Gum benjamin, 785

Gum dragon, 785

Gum tragacanth, 785

Gummi africanum, 1

Gummi arabicum, 1

Gummi mimosae, 1

Gypsum, 105

calcined, 106

dried, 106

Halite, 673

Halocarbon 152a, 242

Halofantrine, 424

Halon, 176

Haloperidol, 798

Hard fat, 762

Hard fat suppository bases, 456, 762

additives, 762

chemical reactivity, 762

melting characteristics, 762

rheology, 762

Hard fat triglyceride esters, 762 Hard paraffin, 503

Hard water, 805

Hard wax, 503

alternatives, 800 Hardening agents (suppositories)

hydrogenated vegetable oil, 800 stearic acid, 737

Hartolan, 402

Hatcol DBP, 234 HCFCs

HCFC 22, 175

HCFC 142b, 174

see also Hydrochlorofluorocarbons (HCFCs)

HD-Eutanol V PH, 496 HE cellulose, 330

Heavy kaolin, 378

Heavy liquid petrolatum, 471 Heavy magnesium carbonate, 422 Heavy magnesium oxide, 426 Heavy mineral oil, 471

HEC, 330

HE-b-CD, 219

Hectabrite AW, 318

Hectabrite DP, 318

Hector clay, 318

Hectorite, 318, 645

Helianthi annui oleum raffinatum, 760 HEMC, 334

Heptafluoropropane, 321, 773

Hermesetas, 638

Hesperetin-7-rutinoside, 487

Hesperidin, 487

Hesperitin 7-rhamnoglucoside, 487

(E,E)-Hexa-2,4-dienoic acid, 710

Hexadecan-1-ol, 155

Hexadecanoic acid, 501

Hexadecanoic acid 1-methylethyl ester, 376 Hexadecanoic acid isopropyl ester, 376

Hexadecanol, 155

Hexadecoic acid, 501

n-Hexadecyl alcohol, 155

Hexadecylic acid, 501

Hexadecylpyridinium chloride, 157 1-Hexadecylpyridinium chloride

monohydrate, 157 Hexadecyltrimethylammonium bromide,

152–153

Hexadecyltrimethylammonium hydroxide, 152

Hexadexylpyridinium bromide, 158

Hexadienic acid, 710

Hexadienoic acid, 710

(E,E)-Hexa-2,4-dienoic acid, 710

2,4-Hexadienoic acid (E,E)-potassium salt, 609

2,4-Hexadienoic acid potassium salt, 609 2,3,4,7,8,8a-Hexahydro-4-hydroxy-8-

(hydroxymethyl)-8-methyl-1H-3a,7- methanoazulene-3,6-dicarboxylic acid, 650

Hexahydrothymol, 459

1,1'-Hexamethylenebis[5-(4-

chlorophenyl)biguanide] diacetate, 166

1,1'-Hexamethylenebis[5-(4-

chlorophenyl)biguanide] digluconate, 166

1,1'-Hexamethylenebis[5-(4- chlorophenyl)biguanide]dihydrochloride, 166

Hexamic acid, 679

1,2,3,4,5,6-Hexanehexol, 718

Hexaplast M/B, 234

D-erythro-Hex-2-enoic acid, 264

Hexetidine, 323

Hexetidinum, 323

Hexigel, 323

Hexocil, 323

Hexoral, 323

Hextril, 323

HFA 134a, 772

HFA227, 321 HFCs

HFC 134a, 772

HFC 152a, 242

HFC227, 321

see also Hydrofluorocarbons (HFCs)

Hibiclens, 166

Hibiscrub, 166

Hibitane, 166

Hibitane diacetate, 166

High-fructose syrup, 292

Hog gum (caramania gum), 786 Hopper salt, 671

HP-50, 357

HP-55, 357

HP-55S, 357

HP-b-CD, 219

HPMC, 346

HPMCAS, 350

HPMCP, 354

HSA, 16

Huile d’amande, 30 Huile de tournesol, 760

Human albumin solution, 16 Human serum albumin, 16 Humectants

ammonium alginate, 46

cyclomethicone, 222

glycerin, 301

polydextrose, 542

propylene glycol, 624

sodium hyaluronate, 681

sodium lactate, 685

sorbitol, 718

trehalose, 788

triacetin, 790

triethanolamine, 794

xylitol, 824

Hyaluronan, 681

Hyaluronate sodium, 681

Hyaluronic acid, 682

Hyamine 1622, 64

Hyamine 3500, 61

Hydagen CAT, 796 Hydrated ferric oxide, 364 Hydrazine yellow, 198

Hydrocarbons (HC), 247, 325

Hydrochloric acid, 328

concentrated, 328

dilute, 329 Hydrochlorofluorocarbons (HCFCs)

chlorodifluoroethane, 174

nomenclature, 178

Hydrocortisone, 56 Hydrofluoroalkanes (HFAs),

tetrafluoroethane, 772 Hydrofluorocarbons (HFCs)

difluoroethane, 242

heptafluoropropane, 321

tetrafluoroethane, 772

Hydrofol, 501

Hydrofol acid 1255, 406

Hydrofol acid 1295, 406 Hydrogels

hydroxyethyl cellulose, 333

sodium alginate, 656

urethane, 546

Hydrogen oxide, 802

Hydrogen phosphate, 530

Hydrogen sulfate, 758

Hydrogenated castor oil, 130, 801 Hydrogenated cottonseed oil, 800 Hydrogenated isomaltulose, 366

Hydrogenated lanolin, 400

Hydrogenated maltose, 438

Hydrogenated oil, 800

Hydrogenated palatinose, 366 Hydrogenated palm oil, 800 Hydrogenated polyoxyl castor oil, 572 Hydrogenated soybean oil, 800 Hydrogenated vegetable glycerides, 762 Hydrogenated vegetable oil, 800

type I, 207

type II, 801

applications, 801

Hydrogenated vegetable oil, type I, 131, 800 Hydrogenated wool fat, 400

Hydro-o-hydroxypoly(oxy-1,2-ethanediyl), 545

Hydro-o-hydroxypoly(oxyethylene)poly (oxypropylene) poly(oxyethylene) block copolymer, 535

Hydromagnesite, 422

Hydroperfluoropropane, 321

Hydrous lanolin, 404

Hydrous magnesium calcium silicate, 767 Hydrous magnesium silicate, 767 Hydrous wool fat, 404 Hydroxyaluminum distearate, 42

4-Hydroxy-m-anisaldehyde, 798

Hydroxybenzene, 514

4-Hydroxybenzoic acid butyl ester, 83 4-Hydroxybenzoic acid ethyl ester, 287

4-Hydroxybenzoic acid methyl ester, 466 4-Hydroxybenzoic acid propyl ester, 629 2-Hydroxy-1,4-butanedioic acid, 436

Hydroxy-p-cymene, 780

Hydroxy-1,2-ethanedicarboxylic acid, 436

Hydroxy-3-ethoxybenzaldehyde, 276

Hydroxyethyl benzene, 519

Hydroxyethyl cellulose, 281, 330, 335, 339,

348, 352, 464

Hydroxyethyl cellulose ether, 330 2-Hydroxyethyl-b-cyclodextrin, 219

Index 903